A new study reveals sex-specific microglial pathways driving ketamine-induced neuroplasticity in females.

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The death of "Friends" star Matthew Perry, who had high levels of ketamine in his system when he died, and the public use by tech billionaire Elon Musk have pushed ketamine into the global spotlight. Recreational use of the substance, first developed in the 1960s as an anaesthetic, has surged in popularity in recent years — notably in the club scen...

A simple—but experimental—treatment gave me my brain back.

Could psychedelics lead to improved antidepressant or antianxiety therapies?

A new study suggests that perceived stress and depression factor into the relationship between insomnia and hazardous drinking -- perhaps not a surprise. But because the relationship between insomnia and heavy drinking goes in both directions, the influence of stress or depression depends on which condition came first, the analysis found.

If phase 3 trials of MM120 (lysergide d-tartrate) for anxiety and depression are successful, could the LSD-based drug become the first FDA-approved psychedelic?

Considerable efforts have been made in recent decades to discover which substances can help prevent serious diseases and even limit the effects of the aging process. Foremost in this area has been research into the role of antioxidants, which come in numerous forms, such as vitamins, minerals, phenolic constituents, and sulfur compounds, from both foods and herbs. Several herbal teas appear of potential benefit, including the popular Rooibos tea of South Africa. Ordinary kitchen spices, including rosemary, basil, turmeric, and cumin, have been shown to have potent antioxidant action.

Researchers found that ketamine reduces "giving up" behavior in zebrafish by altering astrocyte activity, suggesting its antidepressant effects involve non-neuronal brain cells and promoting resilience against futility-induced passivity.