METAL: Immunity & Respiratory Disorders (Preview)

Gutierrez Ruiz et al. analyzed the lysosomal proteome of pancreatic cancer cells expressing oncogenic KRAS. They identified the GEF DOCK8 as being aberrantly expressed in pancreatic cancer cells, where it controls lysosome morphology. DOCK8 regulates lysosomal actin, which impacts trafficking and secretion of lysosomal cathepsins to promote tumor cell invasion.

How cancer spreads or metastasizes is a big question for cancer researchers and patients. Mayo Clinic researchers studying pancreatic cancer—the third deadliest form of cancer in the U.S.—recently made a discovery that advances knowledge of how metastasis unfolds. They identified a cell-signaling protein that drives pancreatic cancer cell growth that could be a potential therapeutic target.

COVID + THE BRAIN 🧠 There’s been a flurry of new studies published in recent weeks about Covid’s detrimental impact on the brain.This is the aspect of Covid which concerns me most, but which many people seem to be blissfully unaware of.So let’s dig into what we know… 🧵 pic.twitter.com/RnUfGFCImt— Cat in the Hat 🐈‍⬛ 🎩 🇬🇧 (@_CatintheHat) March 2, 2024

A new study may now provide a greater explanation for why many experience prolonged fatigue following COVID-19 infection.

Problems with executive function and recall are appearing even in younger cohorts. Effects will have significant repercussions on quality of life, work productivity, and healthcare costs, experts warn.